Supergirl -- "O Brother, Where Art Thou?" -- Image Number: SPG415b_0621b.jpg -- Pictured: Jon Cryer as Lex Luthor -- Photo: Sergei Bachlakov/The CW -- © 2019 The CW Network, LLC. All Rights Reserved.

At long last, Jon Cryer is making his debut as Lex Luthor.

Supergirl episode 415, “O Brother, Where Art Thou?,” will see Lex return home due to his failing help and needing the help of Lena.

JON CRYER GUEST STARS AS ICONIC DC COMICS’ VILLAIN LEX LUTHOR –Secretly furloughed from prison due to failing health, Lex Luthor (guest star Jon Cryer) visits his sister, Lena (Katie McGrath), to seek her help finding a cure. Savvy as ever, Lena is suspicious of Lex’s motives but when she’s faced with a life and death situation, she must decide how she truly feels about her brother. Meanwhile, Supergirl (Melissa Benoist) and J’onn (David Harewood) face off against Manchester Black (guest star David Ajala). James’ sister Kelly (guest star Azie Tesfai) comes to town.

Supergirl episode 415 airs on March 17, 2019.

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